In this thesis research, the piercing phase of Flow Drill Screwdriving® (FDS®) for joining sheet metal is investigated. Starting from their main characteristics, as well as the process phases for their installation, the author describes the Screws in their main parameters, then focuses on the steps required to correctly install them. Lately, the process parameters are analyzed, mainly axial force applied, torque and rotational speed, followed by the main defects. Consequently, the common applications are described, including the tests needed for reliability assessment. In the next section, the main physics behind these screws is reported, including a state of the art based on available documentation on precedent research and experiments, as well as the experimental set-up adopted for joint mechanical characterization and data on the workpiece material, AW6082-T6.