Compliance is a parameter that describes the ability of blood vessels to expand and then recoil towards its initial form as a response to pressure changes. It can be used to give an estimation of the vessels elasticity and it represents an important cardiovascular risk factor, as compliance decreases with age. In particular, it is related to the arterial stiffness occurring as a consequence to vascular wall pathologies such as atherosclerosis or other wall degenerative changes. Therefore, it is important to be able to measure it accurately and reliably in experimental mock loop reproducing the function of the cardiovascular system. The present thesis aims at developing and testing a low cost and easy to use set-up able to estimate the compliance of vascular vessels models, when inserted in a hydraulic system that replicates realistic conditions.