In the latest years, nanomedicine has gained immense attention, providing promising and innovative therapeutic strategies. This is particularly true for nanosystems employed in cancer treatment, by virtue of the small size of devices and their easily tunable physical and morphological properties, which allow effective interactions at a molecular level with cells. In the present Master Thesis, the purpose is to develop a biomimetic protocell, namely a drug-loaded nanosystem which, thanks to its surface functionalization, is capable to selectively address, be internalized and kill cancer cells, avoiding the typical side-effects associated with conventional therapies. The nanoconstructs are specifically designed to target Multiple Myeloma (MM).