The design of biomaterials has seen a great increase in recent decades, with the specific aim to overcome the inadequacy of traditional materials in addressing the complexity of therapeutic approaches typical of tissue engineering (TE). Polymeric materials, in particular, are undergoing a significant growth in their use as biomaterials for multiple applications. Indeed, compared to metals and ceramics, polymeric biomaterials present many advantages, that include biocompatibility, biodegradability, good mechanical and physical properties and general resistance to common sterilization methods. Moreover, synthetic polymers and especially poly(urethane)s can be ad-hoc engineered enabling the tuning of their characteristics to fit specific applications, which requirements could not be otherwise met.