One of the main applications for nanotechnologies in biomedical field is the preparation of drug delivery systems to have a controlled release of the drug to treat a disease and to limit the possible side-effects of the conventional treatments. The goal of this thesis work is synthesizing mesostructured silica hybrid systems for the vitamin D3 release for the topical treatment of psoriasis: vitamin D3 is an organic molecule produced by the skin that stimulates the cell differentiation, limiting the psoriasis effects. In order to overcome the problems related to the poor bioavailability of vitamin D3 due to its lipophilic behaviour, it is possible to exploit mesostructured silica particles as carriers, taking advantage of their ordered structure, high surface area and biocompatibility.