The present work’s goal is to experimentally define the advantages in terms of NOx and Particulate emissions and thermal efficiency of a split injection, namely an unconventional combustion strategy implemented on a diesel engine, here called Partially Premixed Diesel Combustion (PPCI). The hardware of the experimental setup consists of a single-cylinder, four-stroke, supercharged, direct injection, diesel engine. The software utilized for the computational simulations of the combustion process is AVL Fire, while engine-out data is reprocessed with the help of an Excel code based on the heat balance equation. Initially, a comparison of the Partially Premixed Diesel Combustion with the Conventional Diesel Combustion is carried out at three different engine loads (low, medium and high).