Healthcare monitoring activities often require a device capable of recording high definition signals from muscles, nervous tissue and skin. The ability to detect local small changes on the curvilinear and dynamic surface of tissues in motion, is essential for an accurate understanding of body physiology. While rigid microelectronic often fails in this attempt because of the mechanical mismatch with soft tissues, a standard solution for this challenge relies in the use of electrode arrays fabricated on flexible platforms, in order to acquire the electrical potential at the interface of skin and biological tissue. This master thesis describes the development of a microfabricated array that, in contrast with the traditional approach, aims to measure the minute bio-mechanical pressure and strain stimuli, using SiPo (Silk & Laponite) as an active substrate.