Thanks to Dr. Grattoni, Prof. Demarchi and PhD student Di Trani, this thesis has the task to reproduce in silico the phenomena occurring in electrostatically gated nanofluidic membrane for tunable drug release application in medical devices. The studied device can modulate the flux of an electrically charged drug from internal reservoir to the patient passing through a nanochannels membrane. An electric voltage is applied to channels walls to polarize them and obtain an enrichment or depletion of opposite-charge or same-charge drug, respectively, inside them and achieve an increase or decrease, or even stop, of the specific molecule. Using a finite element model developed with Comsol software, the thesis work is correctly reproducing experimental results obtained by Di Trani's tests, introducing new assumptions on manufacturing features of used membrane.