Cross match test or cross matching includes several steps, before a transfusion or organ transplantation, useful for reducing immunological rejections in receiving patients. This project came from the need for the robotization of the cross match setup which would lead to an organizational, economic and safety benefit for the Immunogenetic area. Nowadays this test takes place manually in immunohematology laboratories. The automation of the test would make the co-presence of two people no longer necessary with the consequent reduction of costs and the error probability. The first step necessary for the thesis work was to examine the entire procedure of the compatibility test to understand each cross match step and to analyze human errors that can arise.