Recent advances in bionanotechnology have paved the way for new tumour treatments, based on the use of nanoconstructs whose properties have been proved to kill cancer cells, throughout a series of different mechanisms of interaction in biological processes. Tuning their properties in order to better understand these mechanisms could improve the chances of treating all those tumours that show little response to standard therapies. Among all types of cancers, pancreatic cancer is nowadays one of the most difficult to be diagnosed, due to the lack of visible symptoms at early stages, and to be treated when it is spread throughout the body.