Samira Giuliana Breban
Relation Between Wall Shear Stress Topological Skeleton Descriptors and Thrombus in Abdominal Aortic Aneurysms.
Rel. Umberto Morbiducci, Valentina Mazzi. Politecnico di Torino, Corso di laurea magistrale in Ingegneria Biomedica, 2020
Abstract
The Aorta Abdominal Aneurysm (AAA) is a vascular pathology characterized by progressive enlargement of the abdominal aorta. The AAA initiation is caused by degradation of the aortic wall, biochemical wall stress and inflammation with immune response. Approximately the 75% of AAAs present intraluminal thrombus (ILT), three-dimensional fibrin structures with blood proteins, blood cells, platelets and cellular debris. The role of ILT within the structural stability of AAA in relation to the risk of rupture has not been entirely clarified. In detail, some studies consider the intraluminal thrombus beneficial because it reduces the pressure-wave impact and the stresses acting on the AAA wall.
Other studies suggest that ILT may deprive the aneurysm wall of oxygen and reduce the wall compliance
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