Cancer is considered among the leading causes of death each year worldwide, with an estimated 13.2 million deaths in 2030 for a global population of 8.3 billion people. To increase the survival rate, researchers focused on developing theranostic systems at the nanoscale, combining therapeutic compound with imaging tools in the same platform, improving drug delivery, pharmaco-kinetics, bio-distribution. In this work, we have investigated the design of an innovative theranostic nanoparticle capable to combine the SPIONs multimodal capabilities (MRI bio-imaging, magnetic targeting and hyperthermia) with more efficient and targeted drug release, exploiting Layer-by-Layer assembly (LbL) technique, using the SPION as a core.