Optical Coherence Tomography (OCT) systems are making rapid progress into various areas ranging from medicine and health science up to non-medical areas such as quality control or biometrics. Various possible configurations are present in literature, but only a few exploit liquid crystals (LCs)-based device as a light source. The strength of OCT systems, compared with other three-dimensional imaging technologies, comes from a higher spatial resolution and a fast scanning rate that allows getting high-quality images of in vivo tissue samples. These qualities make OCT the perfect candidate for ophthalmology purpose, where the human eye moves quickly and randomly. The goal of this work is to demonstrate the interest of liquid-crystals optical based devices.