Atherosclerosis is an important pathology affecting the coronary artery system which leads to the creation of stenoses that cause the narrowing or to the obstruction of the coronary arteries. Since coronary obstruction deprives the myocardium of oxygen-rich blood provoking a possible total heart failure, and because of the diffusion of this kind of pathology, in literature different methods of assessment of coronary stenosis have been proposed. The evaluation of the degree of stenosis is essential in order to find the proper treatment for the patient, therefore the physiological assessment of coronary artery disease has become progressively important in both clinical and research application.