The growing interest in space applications based on CubeSat-like technology requires a new approach even in the Product Assurance domain. In particular, more and more universities worldwide are developing a hands-on training educational programme and there is also an increasing demand among small companies and emerging countries of other-than-educational missions, such as technology demonstration and science application. These small and cheap platforms make extensive use of commercial-off-the-shelf components, so the standardization of nanosatellite environmental testing by tailoring the existing test standard for traditional space products is then a vital step to improve their dependability. This thesis aims at the definition of a novel Product Assurance approach for nanosatellites missions to limit the risk associated with the extended use of COTS and low-cost solutions, and to increase mission success of CubeSats in terms of reliability and availability while keeping them low cost and fast delivery systems.