Due to the recent development in the nanotechnology field for biomedical applications, especially regard the treatment of disease, a new kind of Mesoporous Silica Nanoparticles (MSN) are developed with the co-condensation synthesis and different chemical functionalizations are exploited to investigate the phenomena of cavitation and the production of radicals, when combined with the use of intrinsically safe Ultrasound (US) energies. The cavitation is the process of generation and oscillation of bubbles, using, as source, the gases dissolved in the solution, or carried by external elements such as the nanoparticles, guided by the variation of pressure produced by the US. The transient cavitation appears when the oscillating bubbles increase to a size which is no more able to follow the cyclic pressure variations and is characterized by the collapse of the bubbles with emission of high energies and localized increment of temperatures, which are the cause of the radicals generation.