Giovanni Sparacino
Quantitative Radiomics-Based Approach for Preoperative Prediction of Tumor Consistency and Intraoperative Adherence in Vestibular Schwannomas.
Rel. Kristen Mariko Meiburger, Alen Shahini, Bruna Cotrufo, Raffaele De Marco. Politecnico di Torino, Corso di laurea magistrale in Ingegneria Biomedica, 2026
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Abstract
Vestibular schwannomas are benign tumors arising from Schwann cells of the vestibular branch of the eighth cranial nerve and represent the most common neoplasm of the cerebellopontine angle. Their progressive growth may lead to sensorineural hearing loss, tinnitus, imbalance, and, in advanced cases, compression of brainstem structures. Management options include observation, radiosurgery, and microsurgical resection, with the aim of achieving local tumor control while preserving facial nerve function and adjacent neurological structures. Among the factors influencing surgical strategy and postoperative outcome, tumor consistency and adherence to surrounding neural structures play a crucial role. However, conventional magnetic resonance imaging (MRI) assessment remains largely qualitative and does not directly quantify microstructural properties related to tumor stiffness and fibrous content.
In this context, an objective preoperative characterization of tumor biomechanical and structural properties becomes essential for surgical planning and outcome prediction
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