The new frontiers of space research increasingly require the adoption of extremely lightweight and ultra-thin structures, often characterized by anisotropic materials and capable of operating efficiently in the harsh space environment. Among these, large deployable space structures represent a key technological solution for space observation and telecommunications, as they allow the realization of highly efficient and extended apertures while complying with strict mass and stowage constraints. Due to their slenderness and large dimensions, such structures are typically subjected to complex thermo-mechanical loading conditions, including severe thermal gradients, which may induce deformations and consequently affect their functional performance. In this context, the present study aims to provide an effective and reliable modeling strategy for the analysis of highly extended and structurally complex systems with particular emphasis on the macroscale structural response.