Selen Karakas
Specializing Large Language Models for Biofabrication Protocol Generation through Domain-Specific Fine-Tuning.
Rel. Roberta Bardini, Stefano Di Carlo, Alessandro Savino, Riccardo Smeriglio. Politecnico di Torino, Corso di laurea magistrale in Ingegneria Informatica (Computer Engineering), 2026
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Abstract
Biofabrication is the process of creating biological structures, such as tissues or scaffolds, using living cells and biomaterials. In the laboratory, these processes are described in protocols that provide step-by-step instructions for preparing materials, handling cells, and setting fabrication parameters. These protocols are critical for reproducibility. However, they are usually written in free-form natural language, making them difficult to standardize, compare, or use within computational systems. While formal protocol languages and ontology-based frameworks have been proposed, their adoption remains limited due to the manual effort required to convert existing procedural text into structured formats. Machine-readable protocol formats refer to representations that computational models, digital tools, or automated laboratory systems can directly interpret.
As experiments become more complex, the lack of structured and machine-readable protocol formats limits automation and scalability
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