Proximal femoral fractures are among the most common osteoporosis-related injuries and are projected to affect roughly 21 million individuals worldwide by 2025. These fractures occur predominantly as a consequence of falls, but may also arise as spontaneous failures under paraphysiological loading, particularly in older adults with osteoporosis, who exhibit reduced bone mineral density (BMD). Although BMD is clinically employed to estimate fracture risk, this latter ultimately depends on bone strength—the capacity of bone to withstand physiological, paraphysiological, and pathological loads—which is not fully captured by BMD alone. Computed Tomography (CT)–based finite element (FE) modeling could represent a valid alternative to estimate in vivo the subject-specific femur strength.