The thesis activity is in the framework of the European research project CEREBRO, which aims to develop a new non-invasive brain imaging technique with higher spatial resolution than conventional EEG, which is limited by signal attenuation through the skull. To overcome this limitation, the project proposes acquiring neural signals directly at the brain interface and transmitting them at higher frequencies, reducing the effect of signal loss through skull. This approach requires the design of tens-of-micrometer scale, remotely-powered CMOS circuits capable of detecting very low-amplitude brain signals and enabling wireless transmission. This thesis addresses one of the main challenges of the CEREBRO system by exploring and adapting the concept of the Digital-Based Operational Transconductance Amplifier (DIGOTA) as a neural-interface amplifier.