Francesco Mangano
Synthesis and Characterization of Bismuth-based Nanoparticles for Targeted Computed Tomography Imaging.
Rel. Valentina Alice Cauda, Carly Filgueira. Politecnico di Torino, Corso di laurea magistrale in Ingegneria Biomedica, 2025
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Abstract
The cardiac conduction system (CCS) is responsible for rhythmic and coordinated contraction of the heart by rapidly transmitting electrical impulses through fast-conducting fibers. Conduction abnormalities can manifest as life-threatening arrhythmias. Catheter ablation remains the standard treatment for restoring normal cardiac rhythm, relying heavily on accurate localization of the arrhythmogenic substrate. Intraprocedural visualization of CCS abnormalities would be game changing in precisely guiding ablation to the region of interest and minimizing collateral damage of healthy tissue. Although current imaging modalities such as computed tomography (CT) combined with iodinated contrast agents (ICAs) provide high-resolution anatomical detail, they lack the specificity needed to delineate the CCS for targeted intervention.
The use of ICAs present several limitations, including nephrotoxicity, short half-life, and risk of hypersensitivity reactions in patients
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