Understanding the mechanisms and effectiveness of drug diffusion in human tissues is critical for advancing precision medicine and optimizing therapeutic strategies. This thesis presents a comprehensive bibliographic and methodological review of current approaches for evaluating drug diffusion, emphasizing the integration of pharmacokinetics, thermodynamics, and state-of-the-art imaging technologies. Central to this investigation is the role of magnetic resonance imaging (MRI), with a particular focus on diffusion-weighted imaging (DWI) and dynamic contrast-enhanced (DCE) sequences, which serve as powerful, non-invasive tools for visualizing drug dispersion, assessing tissue permeability, and monitoring pharmacodynamic interactions in vivo. This work inquiries into the application of mathematical and physical models to describe and predict drug transport phenomena.