The human brain exhibits remarkable computational capabilities, inspiring research in both neuromorphic computing and bioelectronic neural interfaces, trying to harness its full potential. Organic mixed ionic-electronic conductors (OMIECs) such as poly(3,4-ethylenedioxythiophene) (PEDOT) have been extensively studied for their role in extracellular neural recording and stimulation, benefiting from their high biocompatibility, porosity, and electrical properties. In parallel, dendritic PEDOT fibers have emerged as promising candidates for neuromorphic computing due to their ability to replicate key synaptic functionalities and to be scaled into networks capable of performing complex computations within reservoir computing systems. Furthermore, optically responsive organic semiconductors such as poly(3-hexylthiophene) (P3HT) have gained interest for neural interfacing, enabling optical stimulation without genetic modifications.