Digital electronics is one of the biggest revolutions in the history of mankind. Over the last fifty years, digital devices have found a wealth of possible applications, ranging from supercomputers to the Internet of Things (IoT). Such a complexity requires appropriate hardware infrastructures, including application specific circuits together with “general purpose accelerators” (like GPUs) that can aid high-level computation in implementing the more and more specific functionalities required in each context. In the majority of domains there is a tendency to include as many specific digital (and even analog) circuits as possible in the same die, resulting in the so-called System On Chips.