Seyed Mohammad Mehdi Hosseini
Uncertainty-aware Renal Cell Carcinoma Subtype Classification.
Rel. Santa Di Cataldo, Francesco Ponzio. Politecnico di Torino, Corso di laurea magistrale in Ict For Smart Societies (Ict Per La Società Del Futuro), 2024
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Abstract
Kidney cancer requires accurate and timely diagnosis to guide effective treatment as a particularly prevalent cancer in older adults. Early detection and the precise identification of cancer subtypes and stages can significantly influence therapeutic decisions which leads to improved patient outcomes, preventing metastasis, and increasing survival rates. Renal cell carcinoma (RCC), the most common form of kidney cancer, is a heterogeneous type of cancer that comprises several subtypes, including clear cell RCC, papillary RCC, chromophobe RCC, and oncocytoma. Each of these subtypes comes with a unique biological behavior and treatment response. Currently, clinicians adopt a step-by-step approach to classify these subtypes based on the level of diagnostic uncertainty, starting with tumor morphology.
While tumor morphology serves as the initial method for evaluation, its reliance on overlapping features, such as similar cellular structures and staining patterns, often introduces ambiguity and complicates accurate classification
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