Pushing the boundaries of the design phase beyond the physical constraints to satisfy the needs imposed by the modern complex structures has led to ongoing advancements in data-processing performance and the development of high-tech software. These tools allow engineers to perform non-linear numerical analysis (NLNA) for reinforced concrete (RC) elements through an exhaustive investigation of the overall structural response under potential load cases. By accounting for non-linearities in material, geometric properties, and boundary conditions, NLNA offers the highest level of approximation for defining the structural model, constitutive laws, and resistance mechanisms. The Codes have proposed several safety formats for the NLNAs of RC structures to address the corresponding source of uncertainty, providing a general framework for integrating them within the Global Resistance Format (GRF) and thus ensuring a balanced tradeoff among safety, efficiency, and cost.