The future of education and learning is facing a number of considerable challenges, as the world rapidly changes and becomes more interconnected and technology-driven. In order to guarantee the readiness of future generations to face these challenges, education plays a fundamental role in equipping them with the necessary skills, abilities, and knowledge. Educational models and environments need to be interactive, flexible, and inclusive, and they should be embedded within the very infrastructure of our cities. This paper is a call for action towards the transformation of our urban landscapes into educational environments. It aims to identify the know-how of transforming our cities into Interactive Learning Cities (ILCs).