One of the most recurring words characterizing 2020’s is sustainability, which has tried to be pursued in almost any field as a requirement, especially for human activities which deeply interfere with the environment; one above all, manufacturing. Lots of new technologies which emerged in the last decades contributed to power sustainability in the manufacturing scenario, for all the three pillars in which sustainability can be declined: social, economic and environmental sustainability. The purpose of this thesis work is to present the concept of Digital Twin (DT), with a deep focus on the so-called Human Digital Twin (HDT) paradigm, a virtual representation of a person which can capture physical, biological and emotional traits.