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Study of buffer ion concentration in fast-scan cyclic voltammetry method using nano-graphitic sensors

Edoardo Lombardi

Study of buffer ion concentration in fast-scan cyclic voltammetry method using nano-graphitic sensors.

Rel. Matteo Cocuzza, Davood Shahrjerdi. Politecnico di Torino, Corso di laurea magistrale in Nanotechnologies For Icts (Nanotecnologie Per Le Ict), 2023

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Abstract:

Point-of-Care diagnostic and implantable devices have been on the rise over the last twenty years due to their numerous benefits in healthcare delivery. In this context, nano-graphitic carbon sensors, along with other types of carbon-based sensors, have emerged as optimal candidates, because they can be assembled into densely packed arrays of microelectrochemical sensors with high performance in neurotransmitters detection. The fast-Scan cyclic voltammetry method is one of the best-known methods for measuring electrochemically active neurotransmitters. One of the important aspects of electrochemical measurements is the buffer solution used in the electrochemical sensing of neurotransmitters. However, the effect of the buffer solution has not yet been studied in FSCV measurements. The aim of this thesis is to investigate how buffer concentration can affect the characteristics of neurotransmitters such as sensitivity or impedance of the sensors. Several experiments were performed in which bioanalytes with different characteristics (dopamine, serotonin and melatonin) were dissolved in a buffer solution (phosphate-buffered saline), varying the concentration of the latter. These measurements were performed with the fast-scan cyclic voltammetry technique and using a custom-made experimental apparatus. The sensor was combined with an integrated readout circuit. The current signal was measured and then digitised using a data acquisition instrument. The results were extracted and analysed with custom-made programs. With this work, the understanding of the electrochemical behaviour of neurotransmitters during sensing experiments can be improved for future applications.

Relators: Matteo Cocuzza, Davood Shahrjerdi
Academic year: 2023/24
Publication type: Electronic
Number of Pages: 62
Subjects:
Corso di laurea: Corso di laurea magistrale in Nanotechnologies For Icts (Nanotecnologie Per Le Ict)
Classe di laurea: New organization > Master science > LM-29 - ELECTRONIC ENGINEERING
Ente in cotutela: NYU Tandon school of Engineering (STATI UNITI D'AMERICA)
Aziende collaboratrici: New York University Tandon School of Engineerng
URI: http://webthesis.biblio.polito.it/id/eprint/28565
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