As electronic products become integral to daily life, their presence in safety-critical automotive systems becomes pervasive. The International Standard Organization (ISO) 26262 standard outlines guidelines for establishing a good level of safety in automotive System-on-Chips (SoCs) but, despite the adherence to this standard, operational failures still remain possible, prompting the need for Safety Mechanisms (SMs) to reduce random hardware faults. Nevertheless, SMs must go through a fine verification and validation phase, often involving fault injection, to ensure that they are compliant with the standard and they work as intended. This thesis examines the unique challenges posed by safety-critical SoCs and their SMs within the automotive sector.