Battery operated devices are highly constraint in energy budget, there is a need for energy-efficient designs. Designing circuits to operate in the Minimum Energy Point (MEP) yields great energy savings, by at least 20%, by reducing supply voltage and operating frequency. The MEP is in the near or sub-threshold region, such that the circuit becomes very sensitive to PVT variations. This thesis proposes a methodology to study and locate the MEP and its relationship with supply voltage, threshold voltage, channel length, body biasing, temperature and process variations, for a RISC-V Ibex CPU synthesized with standard cell libraries characterized for highervoltages with a commercially available 22 nm FDSOI technology.