Laura Cubeddu
A retrospective study on deep brain stimulation effects on impulsivity in Parkinsonian patients.
Rel. Filippo Molinari, Alberto Mazzoni. Politecnico di Torino, Master of science program in Biomedical Engineering, 2023
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Abstract
Parkinson's disease (PD) is a neurodegenerative disorder characterized by motor symptoms such as tremors, rigidity and bradykinesia and non-motor symptoms such as mood disorders, cognitive issues, and impulse control disorders (ICDs). ICDs are often associated with dopamine agonists (DAs), although this association is still debated. DAs are prescribed as an alternative or in combination with levodopa, to reduce levodopa-induced complications such as dyskinesia. Deep brain stimulation (DBS) proves to be a viable alternative: although it is invasive, being localized, it provides a more targeted effect. Moreover, some studies have shown that DBS has an improvement effect not only on motor symptoms but also on impulsive behavior.
However, other studies have found no positive impact or even the appearance of ICD after surgery (de novo ICD)
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