Giovanni Ferrarese
Mucosal rheology in the airways of patients with severe lung disease. A bibliographic, experimental and computational insight.
Rel. Daniele Marchisio. Politecnico di Torino, Corso di laurea magistrale in Ingegneria Chimica E Dei Processi Sostenibili, 2023
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Abstract
Worldwide rising pollution, global warming and demographic explosion over the last decades increase the rate of severe acute (correlated to SARS-Cov-2) and chronical (Asthma, Chronical Obstructive Bronch Pneumopathy (COPB) and cystic fibrosis (CF)) respiratory pathologies. These are associated with a clearance defect that causes congestion basically linked to a change in the production, composition and rheology of bronchial mucus. It trade to the necessity to carry out rheological studies to characterize the behaviour of this viscoelastic shier-thinning fluid. In this context the project undertaken by the experimental and computational research laboratories of the Aix-Marseille University (M2P2 and ISM2) and the C2VN (Cardio-Vascular and Nutrition Research Centre of La Timone University Hospital in Marseille) is about the intensification of research in this field with a dual aim.
First able determine the rheological properties of airway mucus overcoming the problems of small quantity and significant variability (in composition and behaviour) of natural samples
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