The design of freight transport networks is becoming an even more relevant component in the context of the worldwide increasing popularity of e-commerce and increasing export volumes. The focus of this thesis is on a combined transport problem where multiple itineraries are possible for commodities with the same origin and destination locations. The problem targets both the strategic positioning of transshipment warehouses -- the so-called hubs -- and the tactical planning of freight transport. The aim is to achieve the best trade-off between operational costs and service performance. We consider, among others, important real-world conditions on the routing of goods: modular capacities on transfer links between hubs, maximum delivery times of goods, and limits on the number of transshipments.