Tissue-simulating phantoms are crucial in the development of optical imaging techniques, such as Optical Coherence Tomography (OCT), in order to test and compare systems performance, validate simulations and evaluate repeatability and reproducibility. One of the most successful OCT functional extensions is OCT Angiography (OCTA), capable of visualizing the blood flow. Thus, the ideal OCTA phantom should mimic the morphology and optical properties of tissue as well as the vasculature shapes and dimensions with the possibility to perfuse it. In this work, skin mimicking optical phantoms were developed involving both 3D-printing and casting techniques. Firstly, several vessel models were designed tracing the morphology of healthy and pathological microvasculature.