Chronic wound (CW) treatment represents one of the main challenges of modern medicine. As CWs result from a variety of causes, their treatment is particularly difficult and can adversely affect patient’s life. A serious obstacle to CW treatment is represented by bacterial resistance to antibiotics. This thesis aimed at the design of a hydrogel intended to be placed in contact with the bed of CWs to stimulate wound remission, without the use of antibiotics. To obtain this result, an injectable supramolecular (SM) polyurethane (PU) hydrogel was loaded with antioxidant and antibacterial nanoparticles (NPs). The NPs were obtained by combining two plant- derived polyphenolic compounds with antioxidant properties, lignin, and tannic acid.