During the last decades a lot of protocols to implement a secure communication between a client and a server have been designed and standardized. The most used and know protocol to introduce security in a communication is TLS. The most important of TLS competitors turned out to be QUIC, which in recent years has gained significant diffusion and use. If the IoT scenario is considered, another standard very much used is represented by DTLS, a protocol very similar to TLS, but that is built on top of UDP instead of TCP as a difference. The main focus of this thesis is to analyse and compare TLS, DTLS and QUIC protocol from the performance and the security point of view.