The role of Vitamin E in human health has been widely studied since its discovery in 1922. In the beginning it was investigated just as nature's most potent lipid-soluble antioxidant, while now other properties have been discovered as its anti-bacterial, anti-inflammatory and anti-cancer activity. The scientific community has grown its interest in this compound over the past two decades, in particular the research in the biomedical field has brought the most convincing results as concern drug delivery systems, surface coatings, tissue engineering and regeneration, and wound healing. In this thesis, a water-soluble form of Vitamin E, the $\alpha$-tocopherol phosphate, associated with titanium surfaces will be discussed.