This thesis aims to develop a PCL scaffold with magnetic (M) nanoparticles (NPs) or core-shell magnetic-silica nanoparticles (Si-MNPs) coating for bone cancer applications. Scaffolds were produced with Bioscaffolder 3.0 (Gesim) melt electro-writing (MEW), a high-resolution additive manufacturing (AM) method for printing highly porous scaffolds composed of synthetic biodegradable polymers. In the beginning, PCL from the printer was used, later it was replaced by PCL from Sigma Aldrich (45kDa). Then, after an alkaline treatment on the scaffold surface (for 1h, 2h and 3h), MNPs and Si-MNPs coatings were synthesized. Afterward, the scaffold’s physical, mechanical, and biological properties were investigated. In particular, Scanning Electron Microscopy (SEM) images illustrated the morphology of the scaffold’s fibers.