The development of advanced microelectrode array (MEA) technology interfaced with low-noise high-gain conditioning circuits is crucial for evaluating the electrophysiological properties of neurons. The simultaneous and parallel access to the activity of a large population of neurons within a network aids the investigation of information processing and learning aspects of neural behavior. This project presents an early-stage design phase of a low-cost electronic readout circuit interfaced with Micro-Graphitic Diamond Multi-Electrode Arrays (µG-D-MEAs), for the real-time monitoring of the activity of cultured neurons in a potentiometric configuration. The developed Analog Front-End (AFE) is a single-channel device consisting of multiple amplifying and filtering stages.