While, over the past few years, CubeSat technology started to become popular, another fundamental and innovative aspect stands out, such as the Intelligent Health and Mission Management (IHMM). “Intelligence is the ability to adapt to change”, Stephen Hawking said during his Oxford University graduation speech. Intelligence, adapt, change. These are the key words of this quote that it is important to focus on. IHMM systems, in effect, allow to predict degradation of subsystems performance, implementing real-time system health forecasts that permit to have enough time to detect, identify and suddenly recover a possible fault, guaranteeing CubeSat safety and letting the system fulfil its operations, while ensuring an acceptable quality of functional capability.