Nowadays, there is a growing interest for flexible strain and pressure sensors due to the increasing demand in several applications fields like industrial, automotive, robotics, biomedical and many others. Conventional sensors have excellent sensitivities but show severe limitations due to their mechanical properties and poor flexibility, which can be overcome by using nanostructured materials. Nanostructured materials show unique and excellent properties with respect to their macroscopic counterparts. Their most important property is the high surface area to volume ratio, which offers interesting possibilities in several applications, as the improved sensitivity, electrical and mechanical performances in flexible sensors. Inside the nanoscale world, nanofibers by electrospinning are an emerging class in the sensing field, since they can be obtained by a simple, low cost and versatile process if compared to other types of nanostructures manufacturing methods.