This thesis aims to define a proper reliable procedure to characterize the fatigue resistance of bituminous mixtures according to European standards. This is achieved by using the four-point bending beam test device under strain-controlled sinusoidal loading configuration at different strain levels, with a reference frequency of 10 Hz, and a constant temperature of 20 °C. By analysing the vast literature on the subject, five failure criteria were selected and compared to come up with the best path to follow for fatigue resistance characterization. The first two failure criteria are based on the modulus reduction: 50 % reduction in the initial modulus taken at the 100th cycle, and 50 % reduction in the modulus extrapolated from the phase of linear reduction of the modulus (Intermediate phase).