Buildings are responsible for more than a third of the global carbon emission, and this number will increase unless there are some significant breakthroughs in the way they are built and managed. In addition, most sustainable buildings are also not performing as well as expected. For such reasons, it is crucial to make buildings more intelligent from their construction to their end of life. The number of factors affecting a building efficiency, sustainability, and performance is so numerous that it is essentially impossible to consider all of them during the design process and even if it is achievable to optimize the design with the most accurate assumptions; over the lifespan of the building, many of these factors might alter or act unpredictably.