My thesis will focus on the role of Geomatics in supporting the analysis and documentation of archaeological sites with geomatics technologies. More specifically, assessing the possibility to extract and investigate additional valuable information based on multi-temporal imagery acquired by UAVs (Unmanned Aerial Vehicles) with visible and NIR (Near-Infrared) sensors. The case study selected for the investigations is Hierapolis of Phrygia, Turkey. The main issues discussed in the work are the evaluation of positional and thematic accuracy of the generated data, the impact of extracting relevant information from NIR and DSM (Digital Surface Model) data, the assessment of the performance of the different software involved in the various processes and the creation of a GIS of the area of interest.