This dissertation is conducted to find an optimized and comprehensive ventilation system solution for the Murisengo Chalk Mine in the north of Italy. First, we discussed the history of ventilation and different methods have used for this purpose passing times and fundamentals of ventilation have been discussed. Then it’s deliberated why we need ventilation and what are the advantages and benefits of a practical ventilation system. In the third chapter, the common ventilation circuits that are employed currently worldwide are discussed and different designs and schemes related to the specifications of various projects are debated in this section. In the consecutive chapter, different devices used for ventilation purposes have been argued such as different types of fans, air doors, airlocks, regulators, … Then the geological and hydrogeological features of the Murisengo mine have been analyzed.