Leonardo Ortoleva
A network algorithm for exact tests for Hardy-Weinberg equilibrium with X-chromosomal variants.
Rel. Mauro Gasparini, Jan Graffelman. Politecnico di Torino, Corso di laurea magistrale in Ingegneria Informatica (Computer Engineering), 2020
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Abstract
In statistical genetics, the exact test is of fundamental importance to assess whether, in a population, genotypes are distributed according to the Hardy-Weinberg law. Genetic variables are usually filtered on the basis of exact test results to avoid genotyping errors, which can negatively affect subsequent analyses in genetic epidemiology, ecology, forensics among others. It is used to test for statistical independence of the different alleles within the same locus. Given this importance, it is useful to understand which are the current tools to calculate it and how efficient they are. For a bi-allelic context it is possible to use asymptotic tests, such as the chi-square test.
Widening the point of view and taking into account more alleles the data are more scattered within the genotype matrix and the exact test is the most reliable
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