Heart disease is one of the most pathology present nowadays. After a stroke a lot of cardiac cells are lost, especially cardiomyocytes. Then a reparative wound process starts, including the activation of cardiac fibroblasts in myofibroblasts, the production of new extracellular matrix (ECM) and the increasing of collagen content, especially type I and III. All these events lead to myocardial fibrosis and cardiac tissue stiffening. Heart pump capacity result to be impaired and heart failure can occur. Since cardiomyocytes are not able to replicate, scar tissue will not become functional anymore, so heart function will no longer be restored. Nowadays there are no therapies that allow the regeneration of the heart and the only option is a heart transplant.