One of the most promising scientific goals that could change the medical field is to find an accurate drug delivery system on the human body, especially for cancer treatment. In the last years, researchers in fields like bioengineering and nanotechnology have designed biocompatible nanomotors for biomedical applications. After the demonstration of the possibility to adopt the self-propulsion by enzyme catalysis, the dynamics of nanoscale swimmers have been studied in simple fluids like water. The motion of micro- and nano-motors in complex fluids has not been extensively addressed. This thesis aims to understand the motion of enzyme-based nanoparticles, developed in a chemical laboratory, that navigate in a complex fluid: Hylauronic Acid (HA).